The Grandiose Ayatollah wants us to know that when he and his followers bellow "Death to America!" they don't really mean "Death to America!" in toto. They don't, for example, mean "Death to All Americans!" No, indeed. In fact, "Death to America!," claims Khamenei, refers specifically to American "policies" and not to the American populace.
Khamenei doesn't specify which policies he means, but since he's a fanatical Shia totalitarian, it seems clear that policies that are antithetical to his belief system--ones predicated on and engendering Western (infidel) concepts of democracy and individual freedom--are the ones he seeks to destroy.